A TALE nuclease architecture for efficient genome editing. Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Modeling psychiatric disorders with patient-derived iPSCs. Stem cell models of human brain development. An atlas of genetic correlations across human diseases and traits. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Lancet 381, 1371–1379 (2013).Ĭross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 9, 468 (2015).Ĭross-Disorder Group of the Psychiatric Genomics Consortium. A new outlook on mental illnesses: glial involvement beyond the glue. Altered neural connectivity in excitatory and inhibitory cortical circuits in autism. Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia. Lewis, D.A., Curley, A.A., Glausier, J.R. Dendrite and spine modifications in autism and related neurodevelopmental disorders in patients and animal models. Dysregulations of synaptic vesicle trafficking in schizophrenia. Glutamatergic postsynaptic density protein dysfunctions in synaptic plasticity and dendritic spines morphology: relevance to schizophrenia and other behavioral disorders pathophysiology, and implications for novel therapeutic approaches. Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia.

Dendritic spine alterations in schizophrenia. Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders. Neuroimaging in autism spectrum disorder: brain structure and function across the lifespan. Brain-imaging studies of treatment-resistant schizophrenia: a systematic review. Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice. Genome-scale neurogenetics: methodology and meaning. Large-scale genomics unveils the genetic architecture of psychiatric disorders. Grand challenges in global mental health. The Global Burden of Disease: 2004 Update (WHO Press, 2008).Ĭollins, P.Y.

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